Prescription Drugs A Z
Drugs and Medications A-Z. Welcome to our Prescription Drug Info, powered by MediResource. This is your source for easy-to-use information on Canadian prescription drugs. Schedule III and IV drugs are available by prescription, may have five refills in 6 months, and may be ordered orally. Some Schedule V drugs are available over the counter. ** Some of the health risks are directly related to the route of drug administration.
The Z-Drugs
If you get a prescription from a doctor for insomnia medicine, it will probably be one of the Z-drugs. The Z-drugs, which include Lunesta, Ambien, and Sonata, are benzodiazepine receptor agonists. That means they work in a similar way to the benzodiazepine drugs inside the brain. They are GABA agonists meaning they somewhat mimic the action of gamma-Aminobutyric acid, the inhibitory neurotransmitter and thereby induce sleepiness.
Alphabetical List Of Sleep Medications
In the historical timeline of insomnia treatment, these drugs came along after the benzodiazepines. They are better because the side effects are less severe and the not as habit forming. (Benzodiazepines still have a place in medicine for treatment of anxiety and are still used for insomnia, too.)
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These drugs are sometimes referred to as non-benzodiazepine hypnotics or just non-benzodiazepines. That’s a dumb name, if you ask us. Too unspecific and vague, especially if you are not in the context of sleep medicine. Further, even within sleep medicine, there are compounds that are non-benzodiazepine hypnotics that would not be considered part of this class: antihistamines and ramelteon, for instance.
One problem is that the chemists don’t have a category that these drugs all fall into which is narrow enough to signify what medical practitioners are talking about. These drugs are in the categories pyrazolopyrimidines, imidazopyridines or cyclopyrrones, but they are not all in the same category.
Therefore, we prefer the term Z-drugs. The generic names for these drugs all contain the letter Z, and it is as good a name as any.
Eszopiclone is sold under the brand name Lunesta® (manufactured by Sepracor). It is less effective than some other insomnia treatments, but has several unique advantages. Eszopiclone has a much smaller chance of causing user dependence than other sleep aids, and is less likely to be used recreationally. It also works well for long-term use. The most frequent side effects reported are loss of coordination and dizziness.
Zaleplon is mainly used to treat insomnia, and is manufactured by King Pharmaceuticals under the brand name Sonata®. Although zaleplon is not a benzodiazepine, it produces many of the same side effects: anterograde amnesia (inability to remember, especially during the period of the drug’s use), confusion, daytime drowsiness, agitation, and hallucinations. Zaleplon is a habit-forming drug. 300 games to play.
Zolpidem is manufactured under several trade names; the most familiar being Sanofi-Aventis’ Ambien®. It is indicated for short-term insomnia treatment. Prescription Ambien is used as a “no-go” pill by the U.S. Air Force to facilitate sleep for pilots after a mission. Zolpidem is also used off-label to manage restless legs syndrome. If taken for an extended period, zolpidem has the potential to become addictive or at least to induce dependence. It produces many side effects, among them: hallucinations and/or delusions, anterograde amnesia, decreased motor coordination, and impaired judgement.
Zopiclone is a short-acting hypnotic drug first developed by Sepracor, and currently produced by Sanofi-Aventis. In the United States, it is sold under the analogue of eszopiclone (see above), and sold under multiple other brand names worldwide. The most commonly reported side effects are a bitter metallic taste, dry mouth, and headache.
The Difference between Z-drugs and Benzodiazepines
Both benzodiazepine drugs and these non-benzodiazepine sedatives work in the brain on the gamma-aminobutyric acid-A (GABA-A) receptors, as do many drugs used to induce sleep. They may not be formal agonists (in the sense that they don’t directly compete with GABA for biochemical sites in the neurons), but they bind to other places near or in the receptors. Benzodiazepines act on GABA-A receptors that include subunits of the alpha-1, alpha-2, alpha-3, and other classes. The Z-drugs are more selective for the alpha-1 subclass which seems to drive sleepiness but not anti-anxiety.
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From 2010 to 2015, annual overdose deaths involving opioids in the United States increased by nearly 57%, with a notable rise in deaths attributed to synthetic opioids other than methadone. Simcity product codes. A new Prescription Behavior Surveillance System (PBSS) Issue Brief compares trends in synthetic opioid overdose deaths in five states. The data show a close association between rising synthetic opioid overdose deaths and the rising availability of illicitly manufactured fentanyl.
Data released by the Commonwealth of Kentucky examines the relationship between rates of Neonatal Abstinence Syndrome (NAS) in various regions of the state versus risky opioid prescribing behaviors observed in these same regions. In the wake of the ongoing opioid epidemic, NAS has greatly increased nationwide, more than tripling from 2004 to 2013. Findings in Kentucky reveal a close association between NAS and high opioid prescribing rates in the preceding year among women of childbearing age.
An analysis of Washington prescription drug monitoring program (PDMP) data revealed that multiple provider episodes (MPEs) vary by age group and class of prescription drug. Opioids and opioid combinations had the highest number of days of overlapping prescriptions, and eight opioids had a mean daily dosage greater than 120 morphine milligram equivalents (MME). Findings indicate that MPEs, overlapping prescription, and mean daily dosages over 100 MMEs are patient risk factors to look for in PDMP data.
Maine’s PDMP data was analyzed to examine several patient risk measures for prescription drug misuse, abuse and overdose. Patients aged 35-54 had the highest rate of MPEs, and opioids were the drug class most frequently involved with MPEs. However, the rate of MPEs declined from 2010 to 2014, and this coincided with an increase in prescribing of buprenorphine, widely used in treating opioid dependence.